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GAGLIANO LAB

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Spleen tyrosine kinase (SYK) inhibition suppresses growth of gastrointestinal neuroendocrine tumor cells: a pilot study in two cell lines.
Ditsiou A, Toffoli L, Vella V, D'Este F, Gagliano T.Cancer Gene Ther. 2025 Oct 16. doi: 10.1038/s41417-025-00979-5. Online ahead of print.PMID: 41102405
FAK inhibition disrupts tumor growth, apoptosis, and transcriptional regulation in GI-NETs.
Toffoli L, Ditsiou A, Triboli L, Hamm V, Moschioni E, D'Este F, Gagliano T.Endocr Oncol. 2025 Aug 14;5(1):e250052. doi: 10.1530/EO-25-0052. eCollection 2025 Jan.PMID: 40832091
Kinome-Wide Synthetic Lethal Screen Identifies PANK4 as a Modulator of Temozolomide Resistance in Glioblastoma.
Vella V, Ditsiou A, Chalari A, Eravci M, Wooller SK, Gagliano T, Bani C, Kerschbamer E, Karakostas C, Xu B, Zhang Y, Pearl FMG, Lopez G, Peng L, Stebbing J, Klinakis A, Giamas G.Adv Sci (Weinh). 2024 Apr;11(15):e2306027. doi: 10.1002/advs.202306027. Epub 2024 Feb 14.PMID: 38353396
Decoding the Tumour Microenvironment: Molecular Players, Pathways, and Therapeutic Targets in Cancer Treatment.
Malavasi E, Adamo M, Zamprogno E, Vella V, Giamas G, Gagliano T.Cancers (Basel). 2024 Jan 31;16(3):626. doi: 10.3390/cancers16030626.PMID: 38339377
Estrogen receptor status heterogeneity in breast cancer tumor: role in response to endocrine treatment.
Malavasi E, Giamas G, Gagliano T.Cancer Gene Ther. 2023 Jul;30(7):932-935. doi: 10.1038/s41417-023-00618-x. Epub 2023 Apr 21.PMID: 37085602
The multifaceted role of lemur tyrosine kinase 3 in health and disease.
Ditsiou A, Gagliano T, Samuels M, Vella V, Tolias C, Giamas G.Open Biol. 2021 Sep;11(9):210218. doi: 10.1098/rsob.210218. Epub 2021 Sep 29.PMID: 34582708
LMTK3 inhibition affects microtubule stability.
Cilibrasi C, Ditsiou A, Papakyriakou A, Mavridis G, Eravci M, Stebbing J, Gagliano T, Giamas G.Mol Cancer. 2021 Mar 17;20(1):53. doi: 10.1186/s12943-021-01345-3.PMID: 33731143
PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression.
Gagliano T, Shah K, Gargani S, Lao L, Alsaleem M, Chen J, Ntafis V, Huang P, Ditsiou A, Vella V, Yadav K, Bienkowska K, Bresciani G, Kang K, Li L, Carter P, Benstead-Hume G, O'Hanlon T, Dean M, Pearl FM, Lee SC, Rakha EA, Green AR, Kontoyiannis DL, Song E, Stebbing J, Giamas G.J Clin Invest. 2020 Jun 1;130(6):3188-3204. doi: 10.1172/JCI128313.
Androgen receptor signaling regulates the transcriptome of prostate cancer cells by modulating global alternative splicing.
Shah K, Gagliano T, Garland L, O'Hanlon T, Bortolotti D, Gentili V, Rizzo R, Giamas G, Dean M.Oncogene. 2020 Sep;39(39):6172-6189. doi: 10.1038/s41388-020-01429-2. Epub 2020 Aug 20.PMID: 32820253 Free PMC article.
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